Emmanuelle JOUANGUY | Institut Imagine

Presentation

PhD, DR2, PI

Emmanuelle JOUANGUY

Human genetics of infectious diseases

Contact :

01 42 75 43 18

emmanuelle.jouanguy@inserm.fr

About

Scientific Publications

Publications

2026

Humans homozygous for rare or common hypomorphic IL23R variants are prone to ..., J Exp Med
2026

High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with ..., medRxiv
2026

Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephali..., J Hum Immun
2026

Human LFA-1 governs T cell immune surveillance of the skin., Sci Immunol
2025

Autoantibodies neutralizing type I IFNs in patients with fulminant herpes sim..., J Exp Med
2025

Inherited IL-18BP deficiency in two Egyptian siblings with fulminant viral he..., J Hum Immun
2024

Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I I..., J Exp Med
2024

A sensitive assay for measuring whole-blood responses to type I IFNs., Proc Natl Acad Sci U S A
2024

Tuberculosis in otherwise healthy adults with inherited TNF deficiency., Nature
2024

FLT3L governs the development of partially overlapping hematopoietic lineages..., Cell
2024

Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 o..., J Clin Invest
2024

The immunopathological landscape of human pre-TCRα deficiency: From rare to c..., Science
2024

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-..., J Exp Med
2023

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs n..., Sci Immunol
2023

Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis..., J Exp Med
2023

Rare predicted loss-of-function variants of type I IFN immunity genes are ass..., Genome Med
2022

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculo..., J Exp Med
2022

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneu..., J Exp Med
2022

The risk of COVID-19 death is much greater and age dependent with type I IFN ..., Proc Natl Acad Sci U S A
2021

Autoantibodies neutralizing type I IFNs are present in 4% of uninfected indiv..., Sci Immunol
2021

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life..., Sci Immunol
2021

Humans with inherited T cell CD28 deficiency are susceptible to skin papillom..., Cell
2021

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever..., J Exp Med
2020

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19., Science
2020

Autoantibodies against type I IFNs in patients with life-threatening COVID-19., Science
2019

Identification of an Endoglin Variant Associated With HCV-Related Liver Fibro..., Front Genet
2019

Homozygous gain-of-function mutation in siblings with a syndromic form of re..., Proc Natl Acad Sci U S A
2019

Candidate Predisposition Variants in Kaposi Sarcoma as Detected by Whole-Geno..., Open Forum Infect Dis
2019

Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reacti..., J Exp Med
2019

Inherited IL-18BP deficiency in human fulminant viral hepatitis., J Exp Med
2019

Human inborn errors of immunity to infection affecting cells other than leuko..., Curr Opin Immunol
2018

The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to..., J Exp Med
2007

TLR3 deficiency in patients with herpes simplex encephalitis., Science
2006

Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease., PLoS Genet

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Presentation

About

Scientific Publications

Humans homozygous for rare or common hypomorphic IL23R variants are prone to ..., J Exp Med

High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with ..., medRxiv

Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephali..., J Hum Immun

Human LFA-1 governs T cell immune surveillance of the skin., Sci Immunol

Autoantibodies neutralizing type I IFNs in patients with fulminant herpes sim..., J Exp Med

Inherited IL-18BP deficiency in two Egyptian siblings with fulminant viral he..., J Hum Immun

Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I I..., J Exp Med

A sensitive assay for measuring whole-blood responses to type I IFNs., Proc Natl Acad Sci U S A

Tuberculosis in otherwise healthy adults with inherited TNF deficiency., Nature

FLT3L governs the development of partially overlapping hematopoietic lineages..., Cell

Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB115:02 o..., J Clin Invest*

The immunopathological landscape of human pre-TCRα deficiency: From rare to c..., Science

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-..., J Exp Med

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs n..., Sci Immunol

Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis..., J Exp Med

Rare predicted loss-of-function variants of type I IFN immunity genes are ass..., Genome Med

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculo..., J Exp Med

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneu..., J Exp Med

The risk of COVID-19 death is much greater and age dependent with type I IFN ..., Proc Natl Acad Sci U S A

Autoantibodies neutralizing type I IFNs are present in 4% of uninfected indiv..., Sci Immunol

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life..., Sci Immunol

Humans with inherited T cell CD28 deficiency are susceptible to skin papillom..., Cell

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever..., J Exp Med

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19., Science

Autoantibodies against type I IFNs in patients with life-threatening COVID-19., Science

Identification of an Endoglin Variant Associated With HCV-Related Liver Fibro..., Front Genet

Homozygous gain-of-function mutation in siblings with a syndromic form of re..., Proc Natl Acad Sci U S A

Candidate Predisposition Variants in Kaposi Sarcoma as Detected by Whole-Geno..., Open Forum Infect Dis

Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reacti..., J Exp Med

Inherited IL-18BP deficiency in human fulminant viral hepatitis., J Exp Med

Human inborn errors of immunity to infection affecting cells other than leuko..., Curr Opin Immunol

The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to..., J Exp Med

TLR3 deficiency in patients with herpes simplex encephalitis., Science

Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease., PLoS Genet

Presentation

About

Scientific Publications

Humans homozygous for rare or common hypomorphic IL23R variants are prone to ..., J Exp Med

High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with ..., medRxiv

Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephali..., J Hum Immun

Human LFA-1 governs T cell immune surveillance of the skin., Sci Immunol

Autoantibodies neutralizing type I IFNs in patients with fulminant herpes sim..., J Exp Med

Inherited IL-18BP deficiency in two Egyptian siblings with fulminant viral he..., J Hum Immun

Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I I..., J Exp Med

A sensitive assay for measuring whole-blood responses to type I IFNs., Proc Natl Acad Sci U S A

Tuberculosis in otherwise healthy adults with inherited TNF deficiency., Nature

FLT3L governs the development of partially overlapping hematopoietic lineages..., Cell

Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 o..., J Clin Invest

The immunopathological landscape of human pre-TCRα deficiency: From rare to c..., Science

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-..., J Exp Med

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs n..., Sci Immunol

Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis..., J Exp Med

Rare predicted loss-of-function variants of type I IFN immunity genes are ass..., Genome Med

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculo..., J Exp Med

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneu..., J Exp Med

The risk of COVID-19 death is much greater and age dependent with type I IFN ..., Proc Natl Acad Sci U S A

Autoantibodies neutralizing type I IFNs are present in 4% of uninfected indiv..., Sci Immunol

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life..., Sci Immunol

Humans with inherited T cell CD28 deficiency are susceptible to skin papillom..., Cell

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever..., J Exp Med

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19., Science

Autoantibodies against type I IFNs in patients with life-threatening COVID-19., Science

Identification of an Endoglin Variant Associated With HCV-Related Liver Fibro..., Front Genet

Homozygous gain-of-function mutation in siblings with a syndromic form of re..., Proc Natl Acad Sci U S A

Candidate Predisposition Variants in Kaposi Sarcoma as Detected by Whole-Geno..., Open Forum Infect Dis

Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reacti..., J Exp Med

Inherited IL-18BP deficiency in human fulminant viral hepatitis., J Exp Med

Human inborn errors of immunity to infection affecting cells other than leuko..., Curr Opin Immunol

The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to..., J Exp Med

TLR3 deficiency in patients with herpes simplex encephalitis., Science

Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease., PLoS Genet

Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB115:02 o..., J Clin Invest*